A 25-year Crohn’s disease mystery finally cracked by AI
Published: November 4, 2025 •
Language: English
UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease. They discovered that the NOD2 gene’s interaction with a protein called girdin is crucial for maintaining balance. When this connection is lost due to a common mutation, inflammation spirals out of control.